1、冷凍電鏡技術和原位結構生物學

2、膜蛋白和複雜超大分子複合體的結構與功能

3、體電鏡技術和構造生物學

4、生命科學儀器研製

2008全國優秀博士論文獎；

2008第八屆“中央國家機關優秀青年”；

2009貝時璋青年生物物理學家獎；

2012所帶團隊榮獲中央國家機關“青年文明號”稱號；

2017中國生物物理學會冷電電子顯微鏡分會 “傑出貢獻獎”；

2018教育部“長江學者獎勵計劃”青年學者；

2020國家傑出青年基金；

2021北京市科學技術進步獎一等獎；

2022中國科學院朱李月華優秀教師獎；

完整論著列表：

https://www.ncbi.nlm.nih.gov/myncbi/1x1Uzxhrkpz5vj/bibliography/public/

代表論著（*為通訊作者）：

1.Xu J, Liao C, Yin CC, Li G*, Zhu Y*,Sun F*. In situ structural insights into the excitation-contraction coupling mechanism of skeletal muscle.Sci Adv2024, 10(12):eadl1126.

2.Tai L, Yin G, Huang X,Sun F*, Zhu Y*. In-cell structural insight into the stability of sperm microtubule doublet.Cell Discov2023, 9(1):116.

3.Li S, Wang Z, Jia X, Niu T, Zhang J, Yin G, Zhang X, Zhu Y*, Ji G*,Sun F*. ELI trifocal microscope: a precise system to prepare target cryo-lamellae for in situ cryo-ET study.Nat Methods2023, 20(2):276-283.

4.Li S, Jia X, Niu T, Zhang X, Qi C, Xu W, Deng H,Sun F*, Ji G*. HOPE-SIM, a cryo-structured illumination fluorescence microscopy system for accurately targeted cryo-electron tomography.Commun Biol2023, 6(1):474.

5.Tai L, Zhu Y, Ren H, Huang X, Zhang C*,Sun F*. 8 Å structure of the outer rings of the Xenopus laevis nuclear pore complex obtained by cryo-EM and AI.Protein Cell2022, 13(10):760-777.

6.Zhang Y, Pang X, Li J, Xu J, Hsu VW*,Sun F*. Structural insights into membrane remodeling by SNX1.Proc Natl Acad Sci U S A2021, 118(10).

7.Du J, Wang D, Fan H, Xu C, Tai L, Lin S, Han S, Tan Q, Wang X, Xu T, Zhang H, Chu X, Yi C, Liu P, Wang X, Zhou Y, Pin JP, Rondard P, Liu H, Liu J*,Sun F*, Wu B*, Zhao Q*. Structures of human mGlu2 and mGlu7 homo- and heterodimers.Nature2021, 594(7864):589-593.

8.Fan H, Wang B, Zhang Y, Zhu Y, Song B, Xu H, Zhai Y, Qiao M*,Sun F*. A cryo-electron microscopy support film formed by 2D crystals of hydrophobin HFBI.Nat Commun2021, 12(1):7257.

9.Zhang J, Zhang D, Sun L, Ji G, Huang X, Niu T, Xu J, Ma C, Zhu Y, Gao N, Xu W,Sun F*. VHUT-cryo-FIB, a method to fabricate frozen hydrated lamellae from tissue specimens for in situ cryo-electron tomography.J Struct Biol2021, 213(3):107763.

10.Qiao A, Han S, Li X, Li Z, Zhao P, Dai A, Chang R, Tai L, Tan Q, Chu X, Ma L, Thorsen TS, Reedtz-Runge S, Yang D, Wang MW, Sexton PM, Wootten D,Sun F*, Zhao Q*, Wu B*. Structural basis of G(s) and G(i) recognition by the human glucagon receptor.Science2020, 367(6484):1346-1352.

11.Huang X, Zhang L, Wen Z, Chen H, Li S, Ji G, Yin CC,Sun F*. Amorphous nickel titanium alloy film: A new choice for cryo electron microscopy sample preparation.Prog Biophys Mol Biol2020, 156:3-13.

12.Zhu G, Zeng H, Zhang S, Juli J, Pang X, Hoffmann J, Zhang Y, Morgner N, Zhu Y*, Peng G*, Michel H*,Sun F*. A 3.3 Å-Resolution Structure of Hyperthermophilic Respiratory Complex III Reveals the Mechanism of Its Thermal Stability.Angew Chem Int Ed Engl2020, 59(1):343-351.

13.Gong H, Li J, Xu A, Tang Y, Ji W, Gao R, Wang S, Yu L, Tian C, Li J, Yen HY, Man Lam S, Shui G, Yang X, Sun Y, Li X, Jia M, Yang C, Jiang B, Lou Z, Robinson CV, Wong LL, Guddat LW,Sun F*, Wang Q*, Rao Z*. An electron transfer path connects subunits of a mycobacterial respiratory supercomplex.Science2018, 362(6418).

14.Wei R, Wang X, Zhang Y, Mukherjee S, Zhang L, Chen Q, Huang X, Jing S, Liu C, Li S, Wang G, Xu Y, Zhu S, Williams AJ,Sun F*, Yin CC*. Structural insights into Ca(2+)-activated long-range allosteric channel gating of RyR1.Cell Res2016, 26(9):977-994.

15.Li S, Ji G*, Shi Y, Klausen LH, Niu T, Wang S, Huang X, Ding W, Zhang X, Dong M, Xu W,Sun F*. High-vacuum optical platform for cryo-CLEM (HOPE): A new solution for non-integrated multiscale correlative light and electron microscopy.J Struct Biol2018, 201(1):63-75.