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專家人才

  • 姓名:Robert Weinkove
  • 性別:
  • 職稱:教授
  • 學曆:博士
  • 電話:
  • 傳真:
  • 電子郵件:rweinkove@malaghan.org.nz
  • 通訊地址廣州市黃埔區開源大道190號

    簡曆:

  • 教育經曆:

    1996年,劍橋大學 克萊爾學院,文學學士

    1999年,倫敦大學 倫敦國王學院,醫學學士和外科學士

    2010-2013年,奧塔哥大學,醫學博士

    工作經曆:

    2018-至今馬拉格漢醫學研究中心 臨床主任

    2012-至今首都和海岸區衛生局血液學家顧問

    2012-2018馬拉格漢醫學研究中心 臨床研究員

    2011倫敦蓋伊/聖托馬斯醫院血液學登記員

    2007-2010馬拉格漢醫學研究中心 臨床研究員

    2004-2007倫敦蓋伊/聖托馬斯醫院血液學登記員

    2003-2004倫敦聖喬治醫院高級醫務官

    2003年 聖詹姆斯大學利茲醫院 重症監護病房醫生

    2002倫敦蓋伊/聖托馬斯醫院 醫務高級幹事

    2001-2002漢諾威醫學院 住院醫生

    1999-2000倫敦蓋伊/聖托馬斯醫院醫學與泌尿泌尿外科醫生

    1999倫敦格林尼治地區醫院 外科主任

    研究領域:

  • 癌症免疫治療的臨床研究、血液腫瘤(主要為B細胞白血病和淋巴瘤)的診斷和管理。

    承擔科研項目情況:

  • 1.已完成了新西蘭健康協會HRC資助的一項可行性試驗一項對乙酰氨基酚在發熱性中性粒細胞減少症作用的隨機安慰劑對照試驗,擔任HRC資助的1/2MELVAC試驗的臨床顧問,該試驗主要研究MIMR製造的自體細胞疫苗治療晚期黑色素瘤患者。

    2.承擔了China-MWC項目:項目名稱:New methods to improve CAR T cell therapy for cancer(提升CAR T細胞抗腫瘤效果的新策略);項目負責人:Rachel Perret, Robert Weinkove,參與人:Peng Li(李鵬), Le Qin(秦樂,;資助金額:492946新幣;項目執行期:2021.09-2023.08

    3.與李鵬組聯合開展了國家自然科學基金課題國際(地區)合作交流項目。項目名稱:含TLR共刺激結構域的嵌合抗原受體T細胞的優化及其抗腫瘤機製研究(項目編號:81961128003),資助直接經費300萬元,執行期間2019.07.01-2022.06.31

    4.與李鵬組聯合開展了廣州市對外科技合作項目,項目名稱:研發新型靶向惡性腫瘤並逆轉腫瘤微環境的細胞免疫治療(項目編號:201907010042),資助經費200萬元,執行周期2019.04.01-2022.03.31

    社會任職:

  • 2019新西蘭衛生研究理事會生物醫學研究委員會成員

    2019ENABLE試驗管理委員會主席

    2019REDDS-2試驗數據安全檢測委員會主席

    獲獎及榮譽:

  • 2019新西蘭衛生研究理事會臨床醫生研究獎學金

    201810榮獲馬拉格漢醫學研究中心臨床醫生研究獎學金

    201211榮獲奧塔哥大學臨床研究博士獎

    代表論著:

  • 1.Burn OK, Farrand K, Pritchard T, Draper S, Tang CW, Mooney AH, Schmidt AJ, Yang SH, Williams GM, Brimble MA, Kandasamy M, Marshall AJ, Clarke K, Painter GF, Hermans IF,Weinkove R. Glycolipid-peptide conjugate vaccines elicit CD8+ T-cell responses and prevent breast cancer metastasis.Clin Transl Immunology. 2022 Jul 3;11(7):e1401.

    2.Jarvis EM, Collings S, Authier-Hall A, Dasyam N, Luey B, Nacey J, Painter GF, Delahunt B, Hermans IF,Weinkove R. Mucosal-Associated Invariant T (MAIT) Cell Dysfunction and PD-1 Expression in Prostate Cancer: Implications for Immunotherapy.Front Immunol. 2021 Oct 19;12:748741.

    3.Weinkove R, George P, Ruka M, Haira TH, Giunti G. Chimeric antigen receptor T-cells in New Zealand: challenges and opportunities.N Z Med J. 2021 Sep 17;134(1542):96-108.

    4.McQuilten ZK, Busija L, Seymour JF, Stanworth S, Wood EM, Kenealy M,Weinkove R; Australasian Leukaemia and Lymphoma Group (ALLG). Hemoglobin is a key determinant of quality of life before and during azacitidine-based therapy for myelodysplasia and low blast count acute myeloid leukemia.Leuk Lymphoma. 2022 Mar;63(3):676-683.

    5.Weinkove R, McQuilten Z, Adler J, Agar M, Blyth E, Cheng A, Conyers R, Haeusler G, Hardie C, Jackson C, Lane S, Middlemiss T, Mollee P, Mulligan S, Ritchie D, Ruka M, Solomon B, Szer J, Thursky K, Wood E, Worth L, Yong M, Slavin M, Teh B. Managing haematology and oncology patients during the COVID-19 pandemic: interim consensus guidance.Med. J. Aust. 2020; 212: 481-9.

    6.George P, Brown A &Weinkove R. B-cell prolymphocytic leukemia with a t(4;14) FGFR3/IGH translocation: response to ibrutinib.Pathology2020; 52: 4912.

    7.Grasso G, Field CS, Tang C-W, Ferguson PM, Compton BJ, Anderson RJ, Painter GF,Weinkove R, Hermans IF, Berridge MV. Vaccines adjuvanted with an NKT cell agonist induce effective T-cell responses in models of CNS lymphoma.Immunotherapy2020; 12: 395406

    8.Dasyam N, George P,Weinkove R. Chimeric antigen receptor T-cell therapies: Optimising the dose.Br J Clin Pharm2020; 86: 167889

    9.George P, Dasyam N, Giunti G, Mester B, Bauer E, Andrews B, Perera T, Ostapowicz T, Frampton C, Li P, Ritchie D, Bollard CM, Hermans IF,Weinkove R. Third-generation anti-CD19 chimeric antigen receptor T-cells incorporating a TLR2 domain for relapsed or refractory B-cell lymphoma: a phase I clinical trial protocol (ENABLE).BMJ Open2020;10:e034629

    10.Dickinson M,Weinkove R. Maintaining a fit T-cell compartment: lymphoma treatment sequencing in the era of CAR T-cell therapies.Int Med J2019; 49: 1338.

    11.Weinkove R,George P, Dasyam N, McLellan A. Selecting costimulatory domains for chimeric antigen rceptors: functional and clinical considerations.Clin Transl Immunology2019; 8: e1049

    12.Weinkove R, Bowden E, Wood C, Campion V, Carter J, Hall R, Weatherall M, Beasley R, Young P. A randomised controlled feasibility trial of paracetamol during febrile neutropenia in hemato-oncology patients.Leukemia & Lymphoma2019; 60: 1540-7

    13.Wheeler M, White G, Brockie S, Dickson M,Weinkove R. Flow cytometric analysis of mechanically disaggregated bone marrow trephine biopsies.Cytometry B Clin Cytom2018; 27: 120-6.

    14.Speir M, Authier-Hall A, Brooks CR, Farrand KJ, Compton BJ, Anderson RJ, Heiser A, Osmond TL, Tang CW, Berzofsky JA, Terabe M, Painter GF, Hermans IF,Weinkove R. Glycolipid-peptide conjugate vaccines enhance CD8+ T cell responses against human viral proteins.Sci Rep.2017; 7: 14273.

    15.Fischer K, Al-Sawaf O, Fink A, Dixon M, Bahlo J, Warburton S, Kipps TK,Weinkove Ret al. Venetoclax and obinutuzumab in chronic lymphocytic leukemia.Blood2017; 129: 2702-5.

    16.Speir M, Hermans IH,Weinkove R. Engaging natural killer T cells asuniversal helpersfor vaccination.Drugs2017; 7: 1-15.

    17.Lucas N, Humble M, Sim D, Balm M, Carter JM,Weinkove R. Temporal changes in neutropenic blood culture isolates and disease associations: a single centre series of 1139 episodes.Int Med J2017; 47: 962-5.

    18.Mo A, McQuilten Z, Wood E,Weinkove R. Red cell transfusion thresholds in myelodysplastic syndromes: A clinician survey to inform future clinical trials.Int Med J2017; 47: 695-8.

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