1. 腫瘤免疫治療研究：靶向肝癌的新型嵌合抗原受體T細胞研發和臨床前評估

2. B急性髓性淋巴細胞白血病的異質性和耐藥機製研究

3. 人源化小鼠研究：腫瘤病人來源的異種移植模型（PDX）、肝髒人源化小鼠模型

1. （2017年）第十九屆中國專利優秀獎、專利名稱：一種免疫缺陷小鼠模型的建立方法、專利號：CN201310229629.9、主要發明人（第三）

2. （2017年）第四屆廣東省專利優秀獎、專利名稱：一種免疫缺陷小鼠模型的建立方法、專利號：CN201310229629.9、主要發明人（第三）

承擔項目情況

1. 國家自然科學基金-麵上項目、“構建用於評估臨床前免疫治療效果的肝癌人源化小鼠模型”、2018-2021年、國家級撥款/80（萬元）、項目負責人

2. 廣東省自然科學基金-博士啟動項目、“CD34陽性/陰性的B-ALL起始細胞群的異質性耐藥機製研究”、2017-2019年、廣東省撥款/10（萬元）、項目負責人

3. 廣州市科技計劃項目（一般項目）、“新型人源化肝髒小鼠模型的構建及其應用”、2019-2021年、廣州市撥款/20（萬元）、項目負責人

期刊論文發表

第一作者論文：

1. Zhiwu Jiang#,Xiaofeng Jiang#, Suimin Chen, Yunxin Lai, Xinru Wei, Baiheng Li, Simiao Lin, Suna Wang, Qiting Wu, Qiubing Liang, Qifa Liu, MuyunPeng, Fenglei Yu, JiangyuWeng, Xin Du, Duanqing Pei, Pentao Liu, Yao Yao, Ping Xue, Peng Li*., Anti-GPC3 CAR T cells suppress the growth of tumour cells in patient-derived xenografts of hepatocellular carcinoma. Front. Immunol. 11 January 2017.（IF=5.511）

2. Zhiwu Jiang#; Manman Deng#; Xinru Wei; Wei Ye; Yiren Xiao; Simiao Lin; Suna Wang; Baiheng Li; Xin Liu; Gong Zhang; Peilong Lai; Jianyu Weng; Donghai Wu; Haijia Chen; Wei Wei; Yuguo Ma; Yangqiu Li; Pentao Liu; Xin Du; Duanqing Pei; Yao Yao; Bing Xu*; Peng Li*.Heterogeneity of CD34 and CD38 expression in adult acute B lymphoblastic leukemia cells is reversible and not hierarchically organized. J Hematol Oncol. 2016 Sep 22;9(1):94.（IF=7.333）

3. Deng M#, Zha J#,Jiang Zhiwu#, Jia X, Shi Y, Li Peng, Chen XL, Fang Z, Du Z, Xu B. Apatinib exhibits anti-leukemia activity in preclinical models of acute lymphoblastic leukemia. J Transl Med. 2018 Feb 28;16(1):47.（IF=4.197）

4. Zhiwu Jiang#, Wu D, Ye W, Weng J, Lai P, Shi P, Guo X, Huang G, Deng Q, Tang Y, Zhao H, Cui S, Lin S, Wang S, Li B, Wu Q, Li Y, Liu P, Pei D, Du X, Yao Y, Li P. Defined, serum/feeder-free conditions for expansion and drug screening of primary B-acute lymphoblastic leukemia. Oncotarget. 2017 Nov 15;8(63):106382-106392.（IF=5.168）

5. Wei Ye#,Zhiwu Jiang#, Xiaoyun Lu, Xiaomei Ren, Manman Deng, Shouheng Lin, Yiren Xiao, Simiao Lin, Suna Wang, Baiheng Li, Yi Zheng, Peilong Lai, Jianyu Weng, Donghai Wu, Yuguo Ma, Xudong Chen, Zhesheng Wen, Yaoyu Chen, Xiaoyan Feng, Yangqiu Li, Pentao Liu, Xin Du, Duanqing Pei, Yao Yao, Bing Xu, Ke Ding*, Peng Li*.GZD824 suppresses the growth of human B cell precursor acute lymphoblastic leukemia cells by inhibiting the SRC kinase and PI3K/AKT pathways. Oncotarget. July 28, 2016.（IF=5.168）

6. Deng M#,Jiang Zhiwu#, Li Y, Zhou Y, Li J, Wang X, Yao Y, Wang W, Li Peng*, Xu B*. Effective elimination of adult B-lineage acute lymphoblastic leukemia by disulfiram/copper complex in vitro and in vivo in patient-derived xenograft models. Oncotarget. 2016 May 17. doi: 10.18632/oncotarget.9413.（IF=5.168）

7. W Ye#;Zhiwu Jiang#; Y Xiao; S Lin; B Jia; Y Li; Z Huang; J Li; F Feng; S Li; H Yao; Z Liu; S Cao; L Xu; Y Li; D Wu; L Zeng; M Zhong; P Liu; Z Wen; B Xu; Y Yao; Y Lai, D Pei*; Peng Li*;. Quantitative evaluation of the immunodeficiency of a mouse strain by tumor engraftments. Journal of Hematology & Oncology. 2015 May 29;8:59. doi: 10.1186/s13045-015-0156-y.（IF=7.333）

8. Wei Li#,Zhiwu Jiang#, Tianzhong Li, Xinru Wei, Yi Zheng, Donghai Wu, Lijian Yang, Shaohua Chen, Bing Xu, Mei Zhong, Jue Jiang, Yufeng Hu, Hexiu Su, Minjie Zhang, Xiaojun Huang, Suxia Geng, Jianyu Weng, Xin Du, Pentao Liu, Yangqiu Li, Hudan Liu, Yao Yao（通訊）and Peng Li（通訊）. Genome-wide analyses identify KLF4 as an important negative regulator in T-cell acute lymphoblastic leukemia through directly inhibiting T-cell associated genes. Molecular Cancer. 2015 14:26. doi:10.1186/s12943-014-0285-x..（IF= 7.776）

9. Zhiwu Jiang, Di Wu, Shouheng Lin and Peng Li., CD34 and CD38 are prognostic biomarkers for acute B lymphoblastic leukemia. Biomarker Research. 2016 4:23.

非第一/通訊作者論文：

1. Zhang Kun; Zhang Ludi; Liu Wenming; Ma Xiaolong; Cen Jin; Sun Zhen; Wang Chenhua; Feng Sisi; Zhang Zhengtao; Yue Liyun; Sun Lulu; Zhu Zhenfeng; Chen Xiaotao; Feng Anqi; Wu Jiaying;Jiang Zhiwu; Li Peng; Cheng Xin; Gao Dong; Peng Luying; Hui Lijian,. InVitro Expansion of Primary Human Hepatocytes with Efficient Liver Repopulation Capacity. Cell Stem Cell. 2018 Oct 30. IF=23.29

2. Chen X, Lai P, Wang Y, He C, Wu S, Huang X, Geng S, Luo C, Ling W, Zeng L, Li Peng,Jiang Zhiwu, Weng J, Du X. Emerging role of C5a/C5aR IL-17A axis in cGVHD. Am J Transl Res. 2018 Jul 15;10(7):2148-2157. eCollection 2018.（IF=3.061）

3. Weng J, Lai P, Qin L, Lai Y,Jiang Z, Luo C, Huang X, Wu S, Shao D, Deng C, Huang L, Lu Z, Zhou M, Zeng L, Chen D, Wang Y, Chen X, Geng S, Robert W, Tang Z, He C, Li P, Du X. A novel generation 1928zT2 CAR T cells induce remission in extramedullary relapse of acute lymphoblastic leukemia. J Hematol Oncol. 2018 Feb 20;11(1):25.

4. Shi P, Zhang L, Chen K,Jiang Z, Deng M, Zha J, Guo X, Li P, Xu B. Low-dose decitabine enhances chidamide-induced apoptosis in adult acute lymphoblast leukemia, especially for p16-deleted patients through DNA damage. Pharmacogenomics. 2017 Aug;18(13):1259-1270.

5. Zhang L, Zhou Y, Chen K, Shi P, Li Y, Deng M,Jiang Z, Wang X, Li P, Xu B. The pan-Bcl2 Inhibitor AT101 Activates the Intrinsic Apoptotic Pathway and Causes DNA Damage in Acute Myeloid Leukemia Stem-Like Cells. Target Oncol. 2017 Oct;12(5):677-687.

6. Xiao Y,Jiang Zhiwu, Li Y, Ye W, Jia B, Zhang M, Xu Y, Wu D, Lai L, Chen Y, Chang Y, Huang X, Liu H, Qing G, Liu P, Li Y, Xu B, Zhong M, Yao Y, Pei D（通訊）, Peng Li（通訊）. ANGPTL7 regulates the expansion and repopulation of human hematopoietic stem and progenitor cells. Haematologica. 2015 Jan 30. pii: haematol.2014.118612. [Epub ahead of print]

7. Yiren Xiao, Xinru Wei,Zhiwu Jiang, Xiangmeng Wang, Wei, Xin Liu, Minjie Zhang, Yan Xu, Donghai Wu, Liangxue Lai, Huihui Yao, Zixia Liu, Su Cao, Pentao Liu, Bing Xu, Yangqiu Li, Yao Yao, Duanqing Pei（通訊）and Peng Li（通訊）. Loss of Angiopoietin-like 7 diminishes the regeneration capacity of hematopoietic stem and progenitor cells. Journal of Hematology & Oncology. J Hematol Oncol. 2015 Feb 6;8(1):7. [Epub ahead of print].

8. Wang G, Li R,Zhiwu Jiang, Gu L, Chen Y, Dai J, Li K. Influenza Virus Induces Inflammatory Response in Mouse Primary Cortical Neurons with Limited Viral Replication. Biomed Res Int. 2016;2016:8076989. doi: 10.1155/2016/8076989.

9. Song J, Zhong J, Guo X , Zhang Q,Jiang Zhiwu, Chen Y, Zou Q, Yang H, Huang J. Li X,Li P, Pei D, Lai L.aJiao , Xiaoping Li3Generation of RAG 1 and 2 deficient rabbits by embryo microinjection of TALENs, Cell Research. 2013, 2013 Aug;23(8)

10. Zhao H, Shi P, Deng M,Jiang Zhiwu, Li Y, Kannappan V, Wang W, Peng Li, Xu B. Low dose triptolide reverses chemoresistance in adult acute lymphoblastic leukemia cells via reactive oxygen species generation and DNA damage response disruption. Oncotarget. 2016 Nov 19. doi: 10.18632/oncotarget.13454.

11. Yin Li, Kai Chen, Yong Zhou, Yiren Xiao, Manman Deng,Zhiwu Jiang, Wei Ye, Xiangmeng Wang, Xinru Wei, Jie Li, Jiabao Liang, Zhongxin Zheng, Yao Yao, Weiguang Wang, Peng Li*, Bing Xu*. A New Strategy to Target Acute Myeloid Leukemia Stem and Progenitor Cells Using Chidamide, a Histone Deacetylase Inhibitor. Current Cancer Drug Targets. 2015;15(6):493-503.

12. Li WZ, Wang GF, Zhang Heng, Shen Yanqin, Dai Jianping, Wu Liqi, Zhou Jianxiang,Jiang Zhiwu, Li Kangsheng, Inability of NS1 protein from an H5N1 influenza virus to activate PI3K/Akt signaling pathway correlates to the enhanced virus replication upon PI3K inhibition. Vet Res, 2012. 43: p.

13. Zeng J, Wang G, Li W, Zhang D, Chen X, Xin G,Jiang, Zhiwu, Li K. Induction of cytopathic effect and cytokines in coxsackievirus B3-infected murine astrocytes. Virol J. 2013 May 21;10:157. doi: 10.1186/1743-422X-10-157.

14. Yang, Song，Kuang, Ye，Li, Hongbo，Liu, Yuehong，Hui, Xiaoyan，Li, Peng，Jiang, Zhiwu，Zhou, Yulai，Wang, Yu，Xu, Aimin，Li, Shiwu，Liu, Pentao，Wu, Donghai(*)，Enhanced Production of Recombinant Secretory Proteins in Pichia pastoris by Optimizing Kex2 P1' site，PLos One，2013，8（9）：1-11.

15. 鄧漫漫;蔣治武;李潔;陳凱;李鵬;周淑芸;徐兵、Disulfiram聯合銅對B淋巴細胞白血病細胞株增殖與凋亡影響機製探討、中華腫瘤防治雜誌, 11期, pp 840-845, 2015.

16. 周健祥,王革非,蔣治武,曾俊,蘇芸,李康生.流感病毒誘導小鼠膠質細胞的細胞因子級聯反應[J].中國免疫學雜誌. 2012(01)

17. 蔣治武,王革非,周健祥,陳小璿,許燕璿,蘇芸,李康生.流感病毒感染小鼠星形膠質細胞誘導GDNF轉錄水平上調[J].中國熱帶醫學. 2012(06)

18. 謝澤鋒,蘇芸,蔣治武,許燕璿,辛崗,李康生. LPS預激神經膠質細胞培養上清對神經元的影響[J].中國熱帶醫學. 2012(06)

會議論文發表

1. Jiang, Zhiwu; Deng, Manman; Xu, Bing; Li, Peng. NO HIERARCHICAL HETEROGENEITY IN ADULT B-ALL LYMPHOID NEOPLASIA. 44th ISEH, 2015/9/17-2015/9/19, p S70, Kyoto, JAPAN, 2015/9.

2. Jiang, Zhiwu;Deng, Manman; Lu, Yi; Xu, Bing; Li, Peng. Heterogeneity of CD34 and CD38 expression in adult acute B lymphoblastic leukemia cells is reversible and not hierarchically organized. 106th Annual Meeting of the American-Association-for-Cancer-Research (AACR), 2015/4/18-2015/4/22, Philadelphia, PA, 2015/8/1.

3. Li, Peng;Jiang, Zhiwu., Identification of growth factors that promote the proliferation and drug resistance of human primary acute B lymphoblastic cells. AACR 107^th, CANCER RESEARCH, 76: 14: 5201

4. Li Lin, Xu Na,Jiang Zhiwu, Lu Qisi, Zhou Xuan, Lu Ziyuan, Huang Jixian, Li Yuling, He Bolin, Pan Chengyun, Li Peng and Liu Xiaoli., EphB4/ephrinB2 ephrinB1 Interaction Mediated Chronic Myelogenous Leukemia Mesenchymal Stromal Cells Osteogenic Differentiation in Vitro and In Vivo. Blood 2016 128:1901; : 58th ASH

5. Xu, B; Li, Y; Chen, K; Zhou, Y; Xiao, YR; Deng, MM;Jiang, ZW; Ye, W ; Wei, XR; Wang, XM; Li, J; Liang, JB; Zheng, ZX; Yao, Y; Wang, WG; Li, P., A New Strategy to Target Acute Myeloid Leukemia Stem and Progenitor Cells Using Chidamide, a Histone Deacetylase Inhibitor. 57th ASH, BLOOD, 126: 23

6. Xu, B ; Deng, MM;Jiang, ZW; Li, J; Chen, K; Li, P., Role of Mitochondrial Apoptotic Pathway in Disulfiram/Copper Mixture-Induced Cell Apoptosis in Human B-Lineage Acute Lymphoblastic Leukemia in Vitro. 57th ASH, BLOOD, 126: 23

專利申請

1. “一種檢測嵌合抗原受體T細胞對肝癌細胞抑製作用的方法”、李鵬、蔣治武、吳迪、林思妙、秦樂、李柏衡、王素娜、吳綺婷、陳冬梅、姚瑤、專利號：CN201611227743.8，已受理；

2. “一種原代細胞的培養方法”、李鵬，蔣治武，林思妙，葉未，姚瑤、專利號：一種人原代細胞培養基及其應用、PCT/CN2015/079846、已進入國家階段；

3. “一種原代B細胞急性淋係白血病細胞的體外培養方法”、李鵬,蔣治武,林思妙,魏新茹、專利號：201410778012.7、專利受理。

4. “一種評估小鼠免疫缺陷程度的方法”、李鵬，葉未，肖毅仁，蔣治武，林思妙，姚瑤，王素娜，李柏衡、專利號：CN201510179449.3、受理階段；

5. “一種免疫缺陷小鼠模型的建立方法”、李鵬，劉誌新，蔣治武，王素娜，鍾梅，賈蓓、專利號：CN201310229629.9，已授權；

6. “一種使BCL11B蛋白降解的方法”、李鵬,李田忠,蔣治武,吳東海、專利號：CN201310199598.7、已授權；（授權公告日：2015.01.21）

7. “一種擴增臍帶血造血幹細胞的細胞因子及其培養基”、李鵬,肖毅仁,蔣治武,賴允鑫,姚瑤、專利號：CN201310349485.0、已授權；（授權公告日：2016.06.29）

8. “一種人體造血幹細胞分化培養方法”、李鵬,李巍,蔣治武、專利號：CN201310349474.2、已授權；（授權公告日：2016.06.15）