首頁>> 中文>> 專家人才

專家人才

  • 姓名:鮑習琛
  • 性別:
  • 職稱:研究員
  • 學曆:博士
  • 電話:
  • 傳真:
  • 電子郵件:bao_xichen@gibh.ac.cn
  • 通訊地址廣州市科學城開源大道190號

    簡曆:

  • 2011年畢業於中國科學技術大學,獲得博士學位;畢業後加入betway体育下载 ,曆任助理研究員,副研究員,研究員,課題組長,博士生導師。

    研究領域:

  • RNA被認為是生命演化過程中出現最早的生物大分子,孕育地球生命的發生和發展。哺乳動物細胞基因組被廣泛轉錄,其中1-2%的區域編碼蛋白質,其餘產生了大量的所謂基因組中的“暗物質”-非編碼RNA。這些RNA在細胞命運的調控中行使著重要的功能如調控基因轉錄,信號轉導,翻譯等等。除此之外,新冠大流行極大地推進了mRNA治療相關方麵的發展,提供了人類對抗疾病/病原的一個新途徑。本課題組圍繞以上科學問題,重點關注以下研究方向:

    (1)利用化學生物學手段開發RNA-蛋白互作研究的新方法、新技術

    (2)RNA-蛋白相互作用在細胞命運轉變、病理和生理條件下的功能和機製

    (3)利用RNA相關技術實現對疾病的治療和預防

    承擔科研項目情況:

  • 承當國家自然基金委青年項目,麵上項目,科技部重點研發計劃,廣東省自然基金委等項目

    社會任職:

  • 國際幹細胞學會(ISSCR)會員;

    The Innovation雜誌青年編委;

    RNA青年委員會委員;

    CNHUPO-YIPA青委會委員

    獲獎及榮譽:

  • 1.廣東省自然科學傑出青年

    2.中國科學院青年創新促進會優秀會員

    3.廣東省自然科學獎勵一等獎(兩項)

    4.廣州市自然科學獎勵一等獎

    5.廣州市珠江科技新星

    代表論著:

  • 1.Ruiqi Zhao#; Xin Fang#; Zhibiao Mai#; Xi Chen; Jing Mo; Yingying Lin; Rui Xiao; Xichen Bao*;

    Xiaocheng Weng*; Xiang Zhou*; Transcriptome-wide identification of single-stranded RNA binding proteins,CHEMICAL SCIENCE, 2023, 14(15): 4038-4047. *共同通訊

    2.Zheng M, Lin Y, Wang W, Zhao Y, Bao X*. Application of nucleoside or nucleotide analogues in RNA dynamics and RNA-binding protein analysis. Wiley Interdiscip Rev RNA. 2022 Feb 25:e1722. doi: 10.1002/wrna.1722. Epub ahead of print. PMID: 35218164. *通訊作者

    3.3. Guo X#, Tariq M#, Lai Y#, Kanwal S#, Lv Y#, Wang X#, Li N, Jiang M, Meng J, Hu J, Yuan J, Luo Z, Ward C, Volpe G, Wang D, Yin M, Qin B, Zhang B*, Bao X*, Esteban MA*. Capture of the newly transcribed RNA interactome using click chemistry. Nat Protoc. 2021 Oct 25. *共同通訊

    4.4. Lv Y#, Bu C#, Meng J, Ward C, Volpe G, Hu J, Jiang M, Guo L, Chen J, Esteban MA*, Bao X*, Cheng Z*. Global Profiling of the Lysine Crotonylome in Different Pluripotent States. Genomics Proteomics Bioinformatics. 2021 Feb;19(1):80-93. *共同通訊

    5.5. Hou L*, Wei Y, Lin Y, Wang X, Lai Y, Yin M, Chen Y, Guo X, Wu S, Zhu Y, Yuan J, Tariq M, Li N, Sun H, Wang H, Zhang X, Chen J, Bao X*, Jauch R*. Concurrent binding to DNA and RNA facilitates the pluripotency reprogramming activity of Sox2. Nucleic Acids Res. 2020 Feb 4:gkaa067. *共同通訊

    6.6. Bao X*,#, Guo X#, Yin M#, Tariq M, Lai Y, Kanwal S, Zhou J, Li N, Lv Y, Pulido-Quetglas C, Wang X, Ji L, Khan MJ, Zhu X, Luo Z, Shao C, Lim DH, Liu X, LiN, Wang W, He M, Liu YL, Ward C, Wang T, Zhang G, Wang D, Yang J, Chen Y, ZhangC, Jauch R, Yang YG, Wang Y, Qin B, Anko ML, Hutchins AP, Sun H, Wang H, Fu XD, Zhang B*, Esteban MA*. Capturing the interactome of newly transcribed RNA. Nat Methods. 2018 Mar;15(3):213-220. *共同通訊

    7.7. Bao X*,#, Wu H#, Zhu X#, Guo X, Hutchins AP, Luo Z, Song H, Chen Y, Lai K, Yin M, Xu L, Zhou L, Chen J, Wang D, Qin B, Frampton J, Tse HF, Pei D, Wang H, Zhang B, Esteban MA*. The p53-induced lincRNA-p21 derails somatic cell reprogramming by sustaining H3K9me3 and CpG methylation at pluripotency gene promoters. Cell Res. 2015 Jan; 25(1): 80-92. *共同通訊

    8.8. Bao X, Zhu X, Liao B, Benda C, Zhuang Q, Pei D, Qin B, Esteban MA. MicroRNAs in somatic cell reprogramming. Curr Opin Cell Biol. 2013 Apr; 25(2): 208-14.

    9.9.Liao B#, Bao X#, Liu L, Feng S, Zovoilis A, Liu W, Xue Y, Cai J, Guo X, Qin B, Zhang R, Wu J, Lai L, Teng M, Niu L, Zhang B, Esteban MA, Pei D. MicroRNA cluster 302-367 enhances somatic cell reprogramming by accelerating a mesenchymal-to-epithelial transition. J Biol Chem. 2011 May 13; 286(19): 17359-64. #共同一作,中科院百篇高引論文

    10.10. Liu J#, Gao M#, He J#, Wu K, Lin S, Jin L, Chen Y, Liu H, Shi J, Wang X, Chang L, Lin Y, Zhao YL, Zhang X, Zhang M, Luo GZ, Wu G, Pei D, Wang J, Bao X, Chen J. The RNA m6A reader YTHDC1 silences retrotransposons and guards ES cell identity. Nature. 2021 Mar;591(7849):322-326.

    11.11.Liu X, Wang X, Li J, Hu S, Deng Y, Yin H, Bao X, Zhang QC, Wang G, Wang B, Shi Q, Shan G. Identification of mecciRNAs and their roles in the mitochondrial entry of proteins. Sci China Life Sci. 2020 Jan 21:10.1007/s11427-020-1631-9.

    12.12. Zhao Y, Zhou J, He L, Li Y, Yuan J, Sun K, Chen X, Bao X, Esteban MA, Sun H, Wang H. MyoD induced enhancer RNA interacts with hnRNPL to activate target gene transcription during myogenic differentiation. Nat Commun. 2019 Dec 19;10(1):5787.

    13.13. Wu Y, Li Y, Zhang H, Huang Y, Zhao P, Tang Y, Qiu X, Ying Y, Li W, Ni S, Zhang M, Liu L, Xu Y, Zhuang Q, Luo Z, Benda C, Song H, Liu B, Lai L, Liu X, Tse HF, Bao X, Chan WY, Esteban MA, Qin B, Pei D. Autophagy and mTORC1 regulate the stochastic phase of somatic cell reprogramming. Nat Cell Biol. 2015 Jun;17(6):715-25.

    14.14. Liu L, Xu Y, He M, Zhang M, Cui F, Lu L, Yao M, Tian W, Benda C, Zhuang Q, Huang Z, Li W, Li X, Zhao P, Fan W, Luo Z, Li Y, Wu Y, Hutchins AP, Wang D, Tse HF, Schambach A, Frampton J, Qin B, Bao X, Yao H, Zhang B, Sun H, Pei D, Wang H, Wang J, Esteban MA. Transcriptional pause release is a rate-limiting step for somatic cell reprogramming. Cell Stem Cell. 2014 Nov 6;15(5):574-88.

Baidu
map